Protein Details: Gamma-aminobutyric acid receptor subunit beta

Protein ID

ICDB_Pro_0433

Protein Name

Gamma-aminobutyric acid receptor subunit beta

Gene Name

Rdl; CG10537

Organism

Drosophila melanogaster (Fruit fly)

Length

606 amino acids

AlphaFoldDB

AF-P25123-F1-model_v4.pdb

Function

Gamma-aminobutyric acid (GABA) receptor voltage channel subunit. GABA; an inhibitory neurotransmitter; mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. Together with glutamate receptor GluClalpha; plays an important role in the visual response by regulating the activity of ON/OFF-selective neurons. Plays a role in promoting sleep and sleep latency by regulating the activity of peptidergic PDF neurons. In large ventral lateral clock neurons; clustering is mediated by Nlg4 and protein levels undergo daily degradation in response to the circadian clock. In neurons in the mushroom bodies; has a role in odor memory acquisition where it inhibits appetitive and aversive olfactory learning; probably upstream of adenylyl cyclase rut and GTPase activating protein Nf1. In male-specific GABAergic neurons; plays a role in inhibiting male aggressive behavior during courtship.; [Isoform D]: Gamma-aminobutyric acid (GABA) receptor voltage channel subunit.

Sequence

MSDSKMDKLARMAPLPRTPLLTIWLAINMALIAQETGHKRIHTVQAATGGGSMLGDVNISAILDSFSVSYDKRVRPNYGGPPVEVGVTMYVLSISSLSEVKMDFTLDFYFRQFWTDPRLAYRKRPGVETLSVGSEFIKNIWVPDTFFVNEKQSYFHIATTSNEFIRVHHSGSITRSIRLTITASCPMNLQYFPMDRQLCHIEIESFGYTMRDIRYKWNEGPNSVGVSSEVSLPQFKVLGHRQRAMEISLTTGNYSRLACEIQFVRSMGYYLIQIYIPSGLIVIISWVSFWLNRNATPARVALGVTTVLTMTTLMSSTNAALPKISYVKSIDVYLGTCFVMVFASLLEYATVGYMAKRIQMRKQRFMAIQKIAEQKKQQLDGANQQQANPNPNANVGGPGGVGVGPGGPGGPGGGVNVGVGMGMGPEHGHGHGHHAHSHGHPHAPKQTVSNRPIGFSNIQQNVGTRGCSIVGPLFQEVRFKVHDPKAHSKGGTLENTVNGGRGGPQSHGPGPGQGGGPPGGGGGGGGGGGPPEGGGDPEAAVPAHLLHPGKVKKDINKLLGITPSDIDKYSRIVFPVCFVCFNLMYWIIYLHVSDVVADDLVLLGEE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed in different parts of the brain: the mushroom bodies (alpha; alpha; beta; beta; gamma lobes and peduncles); the neurons projecting to the columnar-type neuron LC9 optic glomerulus; in interneurons connecting the paired olfactory lobes; antennal lobes; PDF-expressing small and large ventral lateral neurons (LNvs) of the circadian clock and lobula columnar neuron 11 (LC11) (at protein level) (PubMed:18093529; PubMed:19038223; PubMed:19230663; PubMed:24068821; PubMed:29174887; PubMed:32075756; PubMed:32339168). Expressed in all major ON pathway medulla neurons (Mi1; Tm3; Mi4; and Mi9) and in OFF pathway neurons (Tm1; Tm2; Tm4; and Tm9) (PubMed:31535971).

DOI ID

10.1073/pnas.88.16.7209; 10.1073/pnas.91.13.6069; 10.1126/science.287.5461.2185; 10.1186/gb-2002-3-12-research0083; 10.1186/gb-2002-3-12-research0080; 10.1111/j.1471-4159.1993.tb03523.x; 10.1038/363449a0; 10.1113/jphysiol.1994.sp020278; 10.1111/j.1476-5381.1996.tb16720.x; 10.1523/jneurosci.23-11-04625.2003; 10.1126/science.1086763; 10.1016/j.neuron.2007.10.036; 10.1038/nn2046; 10.1016/j.neuron.2008.10.042; 10.1016/j.cub.2009.01.040; 10.1523/jneurosci.4763-08.2009; 10.1523/jneurosci.0819-13.2013; 10.1038/nn.3581; 10.1371/journal.pone.0097468; 10.1016/j.cub.2017.10.052; 10.7554/elife.49373; 10.1016/j.celrep.2020.01.061; 10.1371/journal.pgen.1008727

RefSeq

NP_001261616.1 [P25123-2]; NP_523991.2 [P25123-2]; NP_729461.1 [P25123-1]; NP_729462.2 [P25123-3]